Handicap Inventory." Arch Otolaryngol Head Neck Surg 116(4): 424-7. General outcome measures." Phys Ther 77(9): 890-903. Of life in individuals with vestibular disease using disease-specific and Of daily living scale." Laryngoscope 110(7): 1204-9. "Application of the vestibular disorders activities Of daily living scale." Arch Otolaryngol Head Neck Surg 126(7): 881-7. "Development of the vestibular disorders activities "Mal de debarquement syndrome diagnostic criteria: Consensus document of the Classification Committee of the Barany Society." J Vestib Res 30(5): 285-293. Psychometric properties of the Mobility Inventory for Agoraphobia: Convergent, discriminant, and criterion-related validity. Original paper on the development of the scale, reliability, discriminative validity, treatment sensitivity, and concurrent and construct validity. Behaviour Research and Therapy, 23, 35-44. Chambless, D.L., Caputo, G.C., Jasin, S.E., Gracely, E.J., & Williams, C.Berg K, Wood-Dauphinee S, Williams JI, Gayton D: Measuring balance in the elderly: Preliminary development of an instrument.These primarily involve having people stand in such a way that balance is challenged, and measuring their missteps. There are also numerous tasks used to quantify balance. For the Tinnitus Handicap Inventory, rather few dizzy people are in a lot of distress. So for the Dizziness Handicap Inventory, nearly everyone who is coming to see us in the "dizzy clinic" feels handicapped. There may be a few who are mainly being seen for tinnitus however. These are mainly people who are dizzy, and whose chief complaint is not tinnitus at all. For these, the distribution is much different (n=854). We also have a large repertoire of patients with tinnitus, where we have obtained the THI. These are not "normal" people - these are mainly people with dizziness. For our population of dizzy patients, the median score is about 40 (out of a total of about 1790 patients). Our clinical "dizzy" practice in Chicago uses the DHI frequently. See also separate pages on cognitive and headache questionnaires. Not everyone who had a ping-pong ball drop on their head (i.e an impact), and has headaches has a concussion. Not everyone who is confused has Alzheimer's disease. Or to put this another way, not everyone who has a headache, is having a migraine. It is not based on a blood test, a genetic test, or a brain image. These are diagnoses based on what a patient tells you -symptoms. For example, lets take migraine, PPPD or MdDS. The difficulty here lies in diagnoses that are all symptoms. They have some symptoms that people with concussion have. In other words, someone who scores highly on, lets say, the "Concussion Impact Inventory", doesn't necessarily have a concussion. Pursuing this idea, it is important not to confuse a symptom inventory with a diagnosis. Perhaps they have something else - like a subdural, a brain tumor, a sinus infection. One might wrongly think that someone who scores highly on this survey has migraine. For example, the Migraine disability assessment. Some have unfortunate names, as if they did make diagnoses. None of the questionaires or surveys make "diagnoses". Tinnitus Handicap Inventory/Questionnaire (THI description)Ĭomment: This is not a diagnostic test. Medical outcomes study short form 36 (SF-36).Īdapted from consensus criteria of Staab et al, 2017 Jacobson and Newman, 1990, and several others below.A discussion of DHI norms is here. This is commonly used.Ĭhambliss Mobility Inventory (for Agoraphobia).ĭizziness Handicap Inventory. Powell and Meyers, 1995 Whitney et al, 1999īerg Balance Scale. Activities specific Balance Confidence Scale (ABC)
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The decision to authorise Casgevy has been endorsed by the government’s independent scientific advisory committee, the Commission on Human Medicines, after a robust review of the available evidence. After that, patients may need to spend at least a month in a hospital facility while the treated cells take up residence in the bone marrow and start to make red blood cells with the stable form of haemoglobin. Patients must then undergo conditioning treatment to prepare the bone marrow before the modified cells are infused back into the patient. AdministrationĬasgevy is administered by taking stem cells out of a patient’s bone marrow and editing a gene in the cells in a laboratory. Safety continues to be closely monitored by the MHRA and the manufacturer.īoth trials are ongoing and further results will be made available in due course. No significant safety concerns were identified during the trials. Side effects from treatment were similar to those associated with autologous (from a person’s own cells) stem cell transplants, including (but not limited to) nausea, fatigue, fever and increased risk of infection. The remaining three had more than a 70% reduction in the need for red cell transfusions. Of these, 39 (93%) did not need a red blood cell transfusion for at least 12 months after treatment. In the clinical trial for transfusion-dependent β-thalassemia, 54 patients have currently received Casgevy but only 42 patients have been in the trial long enough to be eligible for the primary efficacy interim analysis. Of these eligible patients, 28 (97%) were free of severe pain crises for at least 12 months after treatment. In the clinical trial for sickle-cell disease, 45 patients have currently received Casgevy but only 29 patients have been in the trial long enough to be eligible for the primary efficacy interim analysis. There are limited medicines currently available to patients, so I welcome today’s news that a new treatment has been judged safe and effective, which has the potential to significantly improve the quality of life for so many. Sickle cell disorder is an incredibly debilitating condition, causing significant pain for the people who live with it and potentially leading to early mortality. John James OBE, Chief Executive of the Sickle Cell Society said: I would like to thank the patients with lived experiences who engaged with us as part of the assessment process and gave us valuable insight into their lives and the challenges of managing their condition. The MHRA will continue to closely monitor the safety and effectiveness of Casgevy, through real-world safety data and post-authorisation safety studies being carried out by the manufacturer. I am pleased to announce that we have authorised an innovative and first-of-its-kind gene-editing treatment called Casgevy, which in trials has been found to restore healthy haemoglobin production in the majority of participants with sickle-cell disease and transfusion-dependent β -thalassaemia, relieving the symptoms of disease. To date, a bone marrow transplant – which must come from a closely matched donor and carries a risk of rejection – has been the only permanent treatment option. Julian Beach, Interim Executive Director of Healthcare Quality and Access at the MHRA said:īoth sickle cell disease and β-thalassemia are painful, life-long conditions that in some cases can be fatal. To do this, stem cells are taken out of bone marrow, edited in a laboratory and then infused back into the patient after which the results have the potential to be life-long. Patients often need a blood transfusion every 3 to 5 weeks, and injections and medicines throughout their lives.Ĭasgevy is designed to work by editing the faulty gene in a patient’s bone marrow stem cells so that the body produces functioning haemoglobin. In people with β-thalassaemia, it can lead to severe anaemia. In people with sickle cell disease, this genetic error can lead to attacks of very severe pain, serious and life-threatening infections, and anaemia (whereby your body has difficulty carrying oxygen). β-thalassemia mainly affects people of Mediterranean, south Asian, southeast Asian and Middle Eastern origin. Sickle cell disease is particularly common in people with an African or Caribbean family background. A new treatment for sickle-cell disease and transfusion-dependent β-thalassemia has been authorised by the Medicines and Healthcare products Regulatory Agency (MHRA) for patients aged 12 and over after a rigorous assessment of its safety, quality and effectiveness.Ĭasgevy is the first medicine to be licensed that uses the innovative gene-editing tool CRISPR, for which its inventors were awarded the Nobel Prize in 2020.īoth sickle cell disease and β-thalassemia are genetic conditions caused by errors in the genes for haemoglobin, which is used by red blood cells to carry oxygen around the body. Despite the principles remaining broadly the same since its inception, modern iterations of radar equipment include new features and technologies, and the mariner should be fully aware of their function and associated limitations. Radar is an important tool for the watchkeeper in all conditions of visibility. In addition, when on international voyages they may also required to carry an electronic chart display and information system (ECDIS). However, they must carry a Global Navigation Satellite System (GNSS) receiver or a terrestrial radio-navigation receiver, Automatic Identification System (AIS), Voyage Data Recorder (VDR) or Simplified Voyage Data Recorder (S-VDR), and a bridge navigational watch alarm system (BNWAS). Ships built before 1 July 2002 may continue to comply with the requirements of SOLAS Chapter V/74 in force prior to 2002 Regulations, regarding Signalling Lamps (Reg. The Merchant Shipping (Safety of Navigation) Regulations 2020 (SI 2020/0673) implement the carriage requirements for navigational equipment set out in Regulation 19 of the International Convention for the Safety of Life at Sea (SOLAS), 1974 Chapter V, a new version of which came in force on 1 July 2002. Provision of navigational equipment on ships In other cases, accidents have occurred where the watchkeeper was found not to be fully familiar with the operation of equipment or its limitations. Watchkeepers must always ensure that positional information is regularly cross checked and verified using other equipment, as well as visual aids to navigation.
Noel Whittaker is the author of Retirement Made Simple and other books on personal finance. Whatever your situation, as the rules change it is a good idea to review your position, and see if a few small changes could up your cashflow. That’s a 7.8 per cent guaranteed return on your money. So by investing $15,000 in a funeral bond and giving $10,000 to charity or your kids, your pension could be increased by $37.50 a week. The upper level at which eligibility for a pension cuts off moves from $954,000 for a homeowner couple to $986,500, and for singles the numbers go from $634,750 to $656,500.įor assets-tested pensioners, every $10,000 reduction in assets is worth about $15 a week in extra pension. The lower level at which the pension starts to reduce has gone up from $419,000 per couple ($280,000 for singles) to 451,500 and $301,750, respectively. The assets test cut-off points will change too. These benefits are available only to part-pensioners because they are due to a change in the taper rates – not to an increase in the amount of pension payable. The big news is that every couple who are part-pensioners now should get a $50-a-week increase in their pension, while singles will get $35 a week. The result is that many part-pensioners will now move to a full pension, and some people who are ineligible for a pension – because they are over the assets test cut-off point – will be eligible to start claiming a part-pension and all the concessions that go with it. It’s an interesting change the pension rates themselves are not changing, but the thresholds that determine how much pension is paid have been adjusted for inflation. Christmas is coming early for many senior citizens, with significant changes to the pension from July 1. Paste and viewer story Instagram on the SSStory.Io. View and Download if you love that photo or Video. Everything you require to know about MyStalk will be covered in this article. Start now Enter the Link Instagram Profile / Username that you want to see their Story anonymously so they dont find out in the Search Bar. Still, using anonymous Instagram-watching apps like MyStalk, you may grab photo reels and stills of your favorite brands, influencers, and celebrities without compromising the quality of the photos.Īfter learning about all the fantastic things it can perform, let’s examine MyStalk’s advantages and disadvantages in greater detail. It is against their terms and conditions. Users cannot download or save other people’s videos or photos to their device’s storage using the official Instagram app. A straightforward fix for each of the minor problems listed above is MyStalk IG viewer. There are situations when you might wish to look for your hidden crush, download your friends’ pictures without their consent, watch someone else’s Instagram story covertly, or, if you’re a parent, keep an eye on what your child is putting on his account behind your back. On the other hand, all viewers will show up in the “Viewers” area and the account owner will receive a notification whenever a story is seen. We make sure your device doesnt leave any trace of us being used as an Insta viewer. When you type someones username into our database to view their insta stories, we redirect you to their Instagram page using a secure connection. Keeping up with the happenings in the lives of individuals you follow on Instagram might be facilitated by using Instagram stories. Our site is 100 legal and works by changing your current IP address for you to view Instagram stories anonymously. The modifiers these Compass Parts add to the game are super difficult, but they also grant super rewards as you play. This is difficult, the rewards more than make up for it.Ĭompass Parts are also similar to Tarot Cards, but on a harder difficulty. They give you modifiers while playing, but you get better rewards if you complete what you are doing. The best way to describe this is like the Skulls in the Halo franchise. Timemark is like that.Īs you play through the endgame, you will see these Tarot Cards come in. Dubbed Fazeer’s Dun’djinn, endgame consists of completing a series of increasingly difficult challenges in more. This is similar to a tower mode in other games where you have to beat a level before going up to the next until you reach the highest level. I’ll be honest - the endgame in Torchlight 3 never really grabbed me. Unlike games like Path of Exile or Diablo 3, in Torchlight 2 its the leveling that matters and why people played it over and over. Also, not everyone play ARPGs by rushing. If you run through one biome 5 times, the cycle ends and the maps randomly get rotated to have new maps for you to run through. So torchlight 2 is in a way a precursor to modern endgame content, though by today standards its now inferior to what others do. But if you do have Beacons, then you are good to go., But watch out for Invasions. These biomes have different modifiers that affect gameplay and how you play, which means you need to adjust your builds to adapt to the new biome around you.īut, if you do not have a Beacon for the biome you want to go through, then you cannot proceed, as Beacons are crucial to access them. When you make it to the endgame of Torchlight Infinite, you will have access to biome. Complete Endgame Guide – Torchlight Infinite Just because you got all the good gear and made it to the end, doesn’t mean you’re done with the game. But what happens when you have successfully got all of the gear that makes you stronger? What’s the endgame here? Well, in this guide, we will show you what you can do in the endgame of Torchlight Infinite. In Torchlight Infinite, you play as the heroes from Torchlight themselves and take them through countless of dungeons and get loot to get better and better. The full version will contain a complete Act 3, a new, not-yet-announced end game experience, and the ability to play Torchlight 3 in Single Player mode, which will not require an internet connection. Torchlight Infinite is another game from the Torchlight franchise that focuses on loot-based ARPG gameplay. QuickTime Player for Macįor years, QuickTime Player has included the ability to record your Mac’s screen. One of the top-used choices is probably already on your Mac, in fact. Some require you to install software on your Mac while others will just run from a browser. In this category, you’ve got several possibilities. Your Choices for Screen Recording Software Without Editing Capabilities With that in mind, I tend to categorize screen recording apps for Mac into two camps: those that include video editing functionality and those that simply record your screen for you. Not always, though, so you might also consider using a screen recorder in tandem with video editing software. In some cases, you might find all the features you need in a single app. These are just some of the features and capabilities you might be looking for in screen recording apps for your Mac. Whatever you choose, you’ll want to be able to include that easily into your project. For that, you may want to record your own voice or use a text-to-speech app. Naturally, you’l probably want to be able to include audio narration, too. If the video has sensitive information in it, like your username or address, maybe you want to be able to blur that out. You will probably want some way to create arrows or other callouts, pointing out what you’re doing. When you’re creating a tutorial for how to accomplish a task on the Mac, you might also need the ability to mark up the video. For example, if you want to record a streaming video with sound, like a lecture or online call, you need audio, too. With all of the different reasons you may want to record your Mac’s screens come a variety of features and capabilities you’ll want. The Nuts & Bolts of Screen Recording Apps for Your Mac Let’s check out some of the best screen recording apps you can find for your Mac. While macOS does include its own screen recording capability by way of QuickTime, that software can only do so much. If you’re helping friends and family with their own tech, recording tutorials can be a game changer. Perhaps you want to keep a recording of an important business meeting. There are plenty of reasons you may need to record your Mac’s screen. Of course, nowadays, this most productive Visual Studio has also applied to the developments of Android, iOS, Windows, Web, and Cloud applications. what you liked, what you thought sucked and what you think is missing.Microsoft’s Visual Studio (written in C++ and C#) has always been the most powerful IDE ( Integrated Development Environment) for C# development. I'd also love to get your feedback on CamStudio. so if you're feeling generous, please get in touch at the email address above and let me know. So, at some point in the near future I'd like to start accepting donations so any coders that work on this project will get some kind of financial reward in addition to the warm, fuzzy feeling they get from helping to resurrect this cracking piece of software. So if there are any Visual C++ programmers out there that have Flash, video encoding and codec experience who'd like a challenge, please get in touch. It doesn't matter if you're at home in Las Vegas or on an Alaskan Cruise - if you've got a laptop or PC you can use CamStudio. The potential for CamStudio to be used as a professional training and support tool is huge and not just in the information technology and internet marketing arenas, but also in diverse markets and tasks like home eduation, recording online geneological research, keeping a video record of special offer prices on your favourite snowboarding (or whatever) website - you get the idea. I've got big plans for CamStudio and want to continously improve it and the Codec as well. If you'd like to be notified when I have some news related to CamStudio, check this page or the forum (link opens a new window) and you'll be kept "in the loop". The forum has been out of action for quite a while now, thanks to spammers however, I do intend on setting up a new support forum and all future V3 support will be handled on there.Ĭ will be moving to a faster hosting setup soon - details to follow. I'm hoping to open source the code in the near future, but right now I want to get CS3 stable enough before I move forward with making the code available. So by downloading CS3 (or CS2.x for that matter) you agree to not hold me liable for any problems either software might cause. I don't think it will cause any issues, damage or generally screw anything up however, I can't 100% guarantee it (no software author can.) Here is the download link, but please be advised, you should class this as an "Alpha" level release. I recommend rebooting your computer after each installation. NET framework ( direct download from Microsoft here)
ehicular traffic is limited to the boat launch area. Vehicular traffic is limited to the boat launch area.Your visit to Snakeden Hollow State Fish and Wildlife Area will be more enjoyable if you follow a few simple rules.Although visitors are welcome, camping is prohibited and there are no picnic areas. Satellites of Snakeden Hollow include the Victoria Pheasant Habitat Area, a 241 -acre parcel 1 mile northwest of Victoria, and the 1680-acre Spoon River State Forest, 8 miles south of Victoria. Small peripheral parking lots for public access have been established off County Road No. The access road to the main lake, boat launch ramp, parking lot and toilets can be reached via County Road No. Take Route 167 east from Victoria to find the site office and hunter check station. The 2,497-acre site is located 1 mile southeast of Victoria in Knox County. Importance is placed on the development of grassland habitat for non-game species through the establishment of warm season grasses, forest plantings and seasonal marshes. Excellent hunting opportunities exist each fall and winter for Canada geese and dove hunting is said to be good. Snakeden Hollow's major management focus is to improve nesting cover, plus resting and feeding areas for the resident flock of giant Canada geese.Īdditional management activities are directed toward upland game, forest and waterfowl production, along with fish and furbearer production in order to allow activities such as hunting and fishing for the general public. The remaining 400 acres are in agricultural leases managed for wildlife habitat. A favorite nesting spot of giant Canada geese, the site has 2,100 acres of grassland, brushy draws, briers, shrubs, cropland and limited hardwood forest. Good wildlife habitat provides a home to numerous species of mammals, birds and reptiles. The water areas currently contain largemouth and smallmouth bass, rainbow and brown trout, muskie, bluegill, redear sunfish, walleye, green sunfish, black crappie, channel catfish and bullhead. All lakes and ponds, except the 160-acre Snakeden Hollow Lake, were formed as the result of surface mining operations. The site contains 125 water impoundments totaling 400 acres. Today, Snakeden Hollow is truly a wildlife paradise. In 1987, the State of Illinois purchased the property from Midland Coal Company and began working with the Soil Conservation Service to mitigate any environmental concerns at the location. This 2,500-acre parcel was a surface mining site for coal from 1962 to 1970 and was considered by many to provide a wealth of opportunity for the development of fish and wildlife habitat. Actually the site is the namesake of a small creek that “snakes” its way through the property. Although the name Snakeden Hollow State Fish and Wildlife Area is rather intimidating, there are no more snakes here than in other areas of the state. It’s not far from memory that many pundits spent months reading Apple’s tea leaves (“rethinking a more modular Mac Pro” might lead to “stackable” Mini-like modules, for example), but it turns out that Apple reverted to the prior decade’s form factor… just, garish. The new Mac Pro is insanely powerful, but man, is that thing ugly. So we certainly understand a lot about them there’s always more to learn but we understand a lot about them.Īpple looks to have delivered on its promise to deliver what the pros wanted. We’ve been talking to them! We’ve actually been going out, meeting with a lot of pro customers to understand how they use our products, what their workflow is like, things they might need. We’ve certainly been getting feedback from a specific group of users in particular, desktop Mac Pro users. At TechCrunch, Matthew Panzarino, recounted Phil Schiller’s approach. Final Thoughtsīack in April, 2017, Apple invited a few selected journalist to Cupertino to discuss tha state of the Mac Pro. Sometimes, Apple’s product release cycle seems opaque. But my thanks goes out to Apple for planning ahead and shipping the 2018 Mac mini-in recognition of this precise customer dilemma. This is a new feeling, that is, not being able to afford a new Mac Pro. The rest of us can, with ongoing joy, fantasize about winning our state’s lottery.įinally, in my own case, when the time comes that my 2013 Mac Pro will no longer run the latest version of macOS, the new (thank goodness) Mac mini, properly configured will do the job for me as a writer and podcaster. Those who need the power of this Mac Pro are those whose business case justifies its cost. Some may complain that it’s too expensive, but we’ve beeen down that road with the iMac Pro. It’s just a shame that Apple took so long to realize that this is the kind of Mac the pros have been hungry for. Clearly, there’s a part of the customer base that Apple wants back badly and for keeps. He let the hardware speak for itself, and we felt it. John Turnus did a great job of delivering a technically exciting but sober approach and revealed the thought that went into the design and engineering. Doing so would have raised the specter of the 2013 hoopla which turned out to be unjustified-in hindsight. Wisely, Apple’s SVP of Product Marketing, Phil Schiller, did not introduce this new Mac Pro. Next, the use of Xeon CPUs suggests strongly that it was premature to go with a suite of A-series CPUs even though many observers, including myself, believe that Apple will go that route eventually. I surmise it requires macOS 10.15 Catalina which is one reason it’ll ship in the fall. What’s more, Apple didn’t hold back or compromise, and it allowed the price to reflect the power of the hardware. It’s going to delight technical and creative professionals. With new Xeon W CPUs, up to 28 cores, a new graphics system called the MPX module, a 1.4 kilowatt power supply, and up to 1.5 TB of RAM, it needn’t feel inferior to any HP Z workstation. It’s the hardware we look to, and hardware is the realm where WWDC, magic and our dreams meet. Whether Apple likes it or not, services don’t convince us of Apple’s ability to innovate. Image credit: Apple Promises Keptįirst, Apple chose the right venue for this announcement. What I want to look at here is the big picture. You can read the tech specs in Apple’s news release and in our own TMO coverage. At the risk of invoking the term “cheese grater 2.0” (everyone else will), Apple has unleashed a powerful new Mac Pro that looks to have fully acknowledged the need of pros and appears to have done everything right. |
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